HAEMATOLOGICAL CHANGES IN LUPUS

Today,I'll discuss about the blood or hematological changes in LUPUS[Systemic lupus erythematosus].The usual change that is observed is anemia[deficiency of the red blood cells or RBCs and/or hemoglobin which is a pigment present within the RBCs which plays a role in the oxygen transport].The anaemia observed in SLE is usually normochromic,normocytic[this means the size and color of the RBCs remain unaltered].

The white blood cell[leucocytes or WBCs] count is often decreased[leucopenia],but usually the lymphocyte[a type of white blood cell] count is decreased,the granulocyte count usually remains unaltered.This usually does not increase the chance of infection.

Thrombocytopenia or reduction of platlet count may be seen.
In some individuals suffering from SLE hemolysis or destruction of the red blood cells may occur.

For any more information on this, please consult your doctor or you may post in the comment section.

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CARDIAC[HEART]CHANGES IN LUPUS

In today's post I'll discuss about the cardiac changes in SLE[systemic lupus erythematosus].Pericarditis[inflammation of the pericardium or the covering of the heart i.e in simple words the pericardium is invaded by different types of inflammatory cells].In minority of cases it may lead to cardiac tamponade.The more serious manifestations may be myocarditis i.e

involvement of muscles of the heart by inflammation:endocarditis.Involvement of the innermost layer of the heart[endocardium] may lead to cardiac valve insufficiencies,usually of the left sided heart valves[aortic and mitral valves].
Of note,myocardial infarction[commonly called only infarction or heart attack] is also common in individuals with lupus,primarily due to accelerated atherosclerosis.

Pericarditis usually responds to anti-inflammatory drugs.Myocarditis and endocarditis is usually treated with glucocorticoids.

For any more information on this, please consult your doctor or you may post in the comment section.

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KIDNEY CHANGES IN LUPUS

In today's post I'll briefly explain the kidney changes [renal changes] in lupus.Kidney involvement is a very serious involvement in Systemic lupus Erythematosus.It is a very important cause of mortality.

In most individuals suffering from SLE, kidney involvement presents with no symptoms,therefore urinalysis should be ordered in any individual with SLE presenting with no symptoms related to the kidney.

Invovement of the kidney may present with proliferative or membranous forms of glomerulonephritis, or with nephrotic syndrome.

Renal biopsy is a very important investigation in these cases,to to determine the course of treatment.

Usually, due to SLE[kidney involvement] needs to be treated by immunosuppressive drugs[steroids and cytotoxic drugs]

If not treated,it may develop into end-stage renal disease.

For further information,please discuss this issue with your doctor.

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