Today i'll present a brief description about an entity called ' drug-induced-lupus '.
Certain drugs,most notorious of them being anti-arrythmic drugs like procainamide,propafenone,disopyramide,antihypertensives like hydralazine etc.
This condition usually presents with fever,lethargy,arthralgia[joint pain],arthritis,myositis etc.Drug-induced lupus is usually positive for ANA and negative for anti-dsDNA.ANA becomes positive even before the symptoms appear.[for information on ANA and anti-dsDNA,please refer to my previous post]
Other drugs causing drug-induced lupus are are...
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antibiotics like minocycline,isoniazid; diuretics like hydrochlorothiazide,anti-thyroid drugs like propylthiouracil,statins like simvastatin,lovastatin;interferons and tumor necrosis factor[TNF] and many others.
One special feature os drug induved lupus is, it is positive for anti-histone antibodies.
For any more information on this, please consult your doctor or you may post in the comment section.
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