Today,I'll present a brief discussion about the auto-antibody tests used for the diagnosis and assessing the chance of complications in LUPUS[SLE].In this post I'll discuss about ANA,anti-dsDNA,anti-SM,anti-Phospholipid antibody and anti-Ro antibody.
The usual initial antibody to be tested is ANA[anti-nuclear antibody].This test is very sensitive that is ANA is positive in vast majority of individuals with SLE.Although ANA NEGATIVE LUPUS may occur,in very rare occasions.
Anti-dsDNA[antibody to double stranded DNA] tests is a very specific test for LUPUS.By specificity it means,that if anti-dsDNA test is positive,there is high chance of the individual having LUPUS[SLE].But the problem with this test ...
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is,anti-dsDNA test is not very sensitive that is,this test is not positive in all individuals with LUPUS.
Anti-SM antibody test is also a very specific test for lupus.
aPL or anti-phospholipid antibody test identify individuals who are at risk of complications like reduced platlet count[thrombocytoenia],fetal loss,clotting within the blood vessels[arterial or venous thrombosis]
Anti-Ro antibodies test,when positive,ascertain higher risk of neonatal lupus,sicca syndrome etc.
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