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The basic medicine in viagra,revatio and many more is actually SILDENAFIL,a phosphodiesterase-5 inhibitor.[PDE-5]
Sildenafil has greatly improved the treatment of erectile dysfunction.This drug is effective in a broad range of causes of erectile dysfunction like diebetogenic[due to diabetes],vasculogenic[disorder of blood vessels],psychogenic,spinal cord injury.It is also effective in cases of erectile dysfunction occurring after radical prostatectomy.
Sildenafil is orally effective.It is metabolized extensively in the body.Sildenafil may be administered in the dosage of 25,50 or 100 mg.Onset os action is usually after one hour.
Sildenafil acts by inhibiting an enzyme called phosphodiesterase-5,thus prolonging the action a chemical called nitric oxide.Nitric oxide[NO] is released from the endothelium[lining cells of the blood vessels] and nerves of the penis during sexual stimulation.NO,then causes relaxation of the muscles of corpora cavernosum[a spongy organ present within the penis,which is mainly responsible for penile tumescence or erection] and that of the blood vessels within the penis,thus resulting in penile engorgement and erection.Sildenafil,by a complex mechanism enhances the action of NO,thereby increasing penile tumescence or erection during sexual arousal.
Due to vasodilatation[vessel dilatation[.the side effects sildenafil may cause are headache,nasal congestion,flushing.Impairment of colour vision may also be an adverse effect of sildenafil.
Sildenafil is contraindicated[must not be taken] in individuals with coronary heart disease and those taking medicines like nitrates in any form, be it oral,sublingual,transnasal or topical.Sildenafil enhance the hypotensive effects of nitrates and thus may lead to very low blood pressure or even shock.
It should also be avoided in patients with congestive heart failure,cardiomyopathy.
Sildenafil should be given very cautiously in individuals with liver disease,kidney disease,bleeding disorders.
It usually does not lead to priapism.Caution is required in individuals with sickle cell anaemia,leukemia,myeloma which predispose to priapism.
Above all,it should always be remembered,that whether you buy Sildanefil[Viagra] online or from medicine shop,it should always be taken after a registered medical practitioner has evaluated the individual,and has prescribed the medicine.Please do not take this medicine without proper prescription of a doctor.
For more information on this,please discuss with your doctor or may post any question in the comment section.
Sildenafil Oral Jelly:Kamagra Jelly
Sildenafil Citrate:Magara, Pfigra, Seagra, Viagra
Sildenafil Soft tabs:Progra Md
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