Google Jan 25, 2009 | Web Health Directory

25 January, 2009

LUPUS AND PREGNANCY

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SYSTEMIC LUPUS ERYTHEMATOSUS [SLE] is an autoimmune disease. In SLE various organs of the body are damaged by auto-antibodies or immune complexes .

In this post , I'll attempt to briefly review the effects of pregnancy in SLE and vice-versa .

EFFECTS OF PREGNANCY IN SLE: Long term prognosis of SLE is usually unaffected . Flare-ups may occur specially in the weeks following delievery [puerperium].Cases of maternal deaths are also reported,the cause in majority , is pulmonary hemorrhage & lupus pneumonitis.

treatment of SLE in pregnancy: The preffered drug to control SLE flare-ups during pregnancy is usually corticosteroids [prednisolone]. Drugs like Azathioprine are also used .
note of caution:analgesics like NSAIDS should be used cautiously, and should never be taken without the proper prescription of your consulting doctor.

EFFECTS OF SLE ON PREGNANCY: Risks of anaemia,leucopenia[less number of leucocytes].thrombocytopenia[reduced number of platlets],renal failure are increased. Propensity for the development of first trimester abortion,recurrent deep vein thrombosis,pregnancy induced hypertension,intra-uterine growth restriction,pre-maturity,still-births etc. are also increased.
In some of the developing babies isolated congenital heart block may occur.

Pre-conceptional counselling is very important in case of SLE and pregnancy.Conception during the period of quiescence is more favorable to the baby.

If any of my friends,need further information on this topic please discuss with your doctor.For any question on this topic, feel free to post in the comment section.


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