GRAFT VERSUS LEUKEMIA EFFECT

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Acute graft versus host disease is a condition in which the graft versus host reaction occurs in the first 3 months of the transplant procedure.Usually it appears in the first 2-4 weeks following transplant.Acute graft versus host disease is characterized by erythematous[reddish] maculopapular skin lesions,anorexia,diarrhea and dysfunctions of the liver with rise in serum bilirubin,SGOT,SGPT.Acute graft versus host disease has been into four stages and four grades.


Acute graft versus host disease is mediated by the T lymphocytes[a variety of blood cell] present in the donor marrow.If the recipient that is an individual who receives the transplant, is transfused with bone marrow depleted of donor T cells,then the chances of Acute graft versus host disease is virtually eliminated.But by this process,the chances of failure of engraftment[graft failure] increases and recurrence of disease in leukemic patients increases.This is called graft versus leukemia effect.

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